Claudia Jacova, PhD

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Roles and Interests

Instructor for Statistics & Research Design

Supervision of PhD dissertation research projects

Research interests: aging, cognitive impairment and dementia; early cognitive and functional MRI-based recognition of cerebrovascular and neurodegenerative disease (e.g., Lacunar infarct, Alzheimer Disease, Frontotemporal Dementia); interventions to promote quality of life in dementia; cognitive and clinical instrument development for disease recognition and monitoring; cross-cultural considerations and human-computer interactions in the context of cognitive impairment and dementia.


Laurea di dottore, University of Florence, Italy, 1985

PhD, University of British Columbia, Vancouver, B.C., 2003

Professional Membership

Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART)

Recent Publications (2008-present)

Jacova, C., Hsiung, G-Y. R., Tawankanjanachot, I., Dinelle, K., et al. (in press). Anterior brain glucose hypometabolism predates dementia in progranulin mutation carriers. Neurology

Chertkow H., Feldman H. H., Jacova C., & Massoud F. (in press). Definitions in dementia and predementia states in Alzheimer Disease and Vascular Cognitive Impairment. Alzheimer’s Research & Therapy,

Lebed, E., Jacova, C., Wang, L., & Beg, M. F. (2013). Novel surface-smoothing based local gyrification index and its use in localizing changes in cortical folding in Alzheimer’s Disease. IEEE Transactions on Medical Imaging, 32(4), 660-669. 

Juarez-Cedillo, T., Sanchez-Arenas, R., Sanchez-Garcia, S., Garcia-Pena, C., Hsiung, G. Y., Sepehry, A. A., Beattie, B. L., Jacova, C. (2012). Prevalence of Mild Cognitive Impairment (MCI) and its subtypes in the Mexican elderly population. Dementia & Geriatric Cognitive Disorders, 34(5-6), 271-281. 

Edwards, J. D., Jacova, C., Sepehry, A., Pratt, B., & Benavente, O. (2013). Domain-specific neuropsychological assessment in symptomatic lacunar stroke: A systematic review. Neurology80(3), 315-322.

Jacova, C., Pearce, L. A., Costello, R., Hart, R. G., & Benavente, O. R. (2012). Cognitive impairment in lacunar strokes: The SPS3 trial. Annals of Neurology72(3), 351-362. 

Sepehry, A. A., Lee, P. E., Hsiung, G-Y. R., Beattie, B. L., & Jacova, C. (2012). Effect of SSRIs in Alzheimer Disease with comorbid depression: A meta-analysis of cognitive and depression outcomes. Drugs & Aging29(10), 793-806. 

Sepehry, A. A., Lee, P. E., Hsiung, G-Y. R., & Jacova, C. (2012). Stay the course – is it justified? Lancet379(9812), 220.

Woodward, M., Hsiung, G-Y. R., Feldman, H., Jacova, C., & Mackenzie, I. R. (2010). Multiple pathologies in dementia are common. European Geriatric Medicine, 1(5), 259-265. 

Liu-Ambrose, T., Eng, J. J., Boyd, L. A., Jacova, C., et al. Promotion of the mind throughexercise (PROMoTE): A proof-of-concept randomized controlled trial of aerobic exercise training in older adults with vascular cognitive impairment. BMC Neurology17, 10-14. 

Woodward, M., Jacova, C., Black, S., et al. (2010). Differentiating the frontal variant of Alzheimer Disease. International Journal of Geriatric Psychiatry, 25(7), 732-738.

Dubois, B., Feldman, H., Jacova, C., et al. (2010). Revising the definition of Alzheimer’s Disease: A new lexicon. Lancet Neurology, 9(11), 1118-1127. 

Feldman, H., & Jacova, C. (2009). Predicting response to acetylcholinesterase inhibitor treatment in Alzheimer disease: Has the time come? Nature Clinical Practice Neurology, 5(3), 128-129.

Feldman, H., Jacova, C., Robillard, A., et al. (2008). The diagnosis of dementia. Canadian Medical Association Journal, 178(7), 825-836. 

Jacova, C., Peters, K. R., Wong, E., et al. (2008). Cognitive-Impairment-No-Dementia (CIND) – neuropsychological and neuroimaging characterization of an amnestic subtype. Dementia and Geriatric Cognitive Disorders, 25(3), 238-247. 

Dubois, B., Feldman, H., Jacova, C., et al. (2007). Research criteria for the diagnosis of Alzheimer’s disease: Revising the NINCDS-ADRDA criteria. Lancet Neurology, 6(8), 734-746. 

Representative Conference Proceedings and Presentations

Sepehry, A. A., Chen, P., Min, H. J., Hsiung, G-Y. R., Beattie, B. L., Lee, P. E., & Jacova, C. (2013, March) Depression of AD: An evidence-based epidemiological systematic review on prevalence and symptoms. Presented at the American Academy of Neurology 65th Annual Meeting, San Diego, Calif. 

Brehmer, M., McGrenere, J., Tang, C., & Jacova, C. (2012). Investigating interruptions in the context of computerized cognitive testing of older adults. In Proceedings of the 30th International Conference on Human Factors in Computing SystemsAustin, Texas (Chi’12, ACM Press 2649-2658).

Jacova, C., Hsiung, G-Y. R., DeJesus Hernandez, M., et al. (2012, September). Presymptomatic C9ORF72 mutation carriers show a diffuse pattern of glucose metabolic reductions on (18)F-FDG-PET imaging. Presented at the 8th International Conference on Frontotemporal Dementia, Manchester, UK. (Dementia & Geriatric Cognitive Disorders, 34Suppl 1), 158.

Wang, B. W., Lu, E., Mackenzie, I. R. A., Assaly, M., Jacova, C., Lee, P. E., Beattie, B. L., & Hsiung, G-Y. R. (2012). Frequency and presentation of multiple pathology in patients enrolled in Alzheimer clinical trials. Presented at the 64th Annual Meeting of the American Academy of Neurology, New Orleans, La.

Jacova, C., Le Huray, S., Feldman, S., et al. (2012). Sensitivity of a computerized test to aphasia: The sentence production subtest from Cognitive Testing on Computer (C-TOC).Presented at the Alzheimer’s Association International Conference, Vancouver, B.C. (Alzheimer’s & DementiaSuppl 8(5), 539-540).

Jacova, C., McGrenere, J., Lee, H., et al. Cognitive testing on computer (C-TOC): Development and validation of a novel computerized testing tool for office and home administration. Presented at the Alzheimer’s Association International Conference, Vancouver, B.C. (Alzheimer’s & Dementia, Suppl 8(5), 540). 

Sepehry, A. A., Ory, J., Yang, L., & Jacova, C. (2011, October). Music therapy and global cognitive change as a function of methodological variables: A systematic review. Presented at the 6th Canadian Conference on Dementia, Toronto, ON.

Jacova, C., Slack P., Ory J., et al. (2011, July). An fMRI study of music familiarity and brain activation in Alzheimer Disease. Poster presented at the Alzheimer’s Association International Conference, Paris, France (Alzheimer’s & Dementia, 7[4 Suppl], S248).

Jacova, C. (2011, March). The ADTI CLIMAT study. Presented at the 26th International Conference of Alzheimer’s Disease International Alzheimer’s Disease International, Toronto, ON.

Limsoontarakul, S., Jacova, C., Hsiung, G-Y. R., et al. (2011, June). fMRI activation during matrix reasoning tasks in presymptomatic FTD. Presented at the Canadian Neurological Sciences Federation, Vancouver, B.C. (Canadian Journal of Neurological Sciences39(3), Suppl 1, S52).

Hallam, B., Jacova, C., Sengdy, P., et al. (2010). Neuropsychological characteristics of presymptomatic, progranulin mutation carriers in the UBC frontotemporal lobar degeneration cohort. Presented at the 7th International Conference on Frontotemporal Dementias, Indianapolis, Ind. (Dementia & Geriatric Cognitive Disorders, 30, Supplement 1, 85).

Tawankanjanachot, I., Jacova, C., Hsiung, G. Y. R., et al. (2010, October). Anterior and subcortical glucose hypometabolic rate in presymptomatic progranulin carriers. Poster at the 7th International Conference on Frontotemporal Dementias, Indianapolis. (Dementia & Geriatric Cognitive Disorders 30, Supplement 1, 82). 

Jacova, C., Lee, H. S., & Le Huray, S., et al (2010, July). Cognitive Testing on Computer (C-TOC): Designing a computerized test battery for evaluation of cognitive impairment with user and community health professional input. Presented at the International Conference on Alzheimer’s Disease, Honolulu, Hawai‘i. (Alzheimer’s & Dementia, 6[4 Suppl 1], S317-18).

Jacova, C., Schulzer, M., Money, J., et al. (2009, October). Social impact as a novel construct in the measurement of clinically meaningful change: Validation data for the Clinical Meaningfulness in Alzheimer Disease Treatment (CLIMAT) scale. Presented at the Canadian Conference on Dementia, Montreal, QB. (Canadian Journal of Geriatrics,12[3],131).  

Hsiung, G. Y. R., Kupferschmidt, A. L., Naus, K., Feldman, H. H., & Jacova, C. (2009, October). Does brain age affect a brain’s age? A pilot study on computerized cognitive training in Mild Cognitive Impairment. Presented at the Canadian Conference on Dementia, Montreal, QB. (Canadian Journal of Geriatrics,12[3],124). 

Jacova, C. (2009, July). Episodic memory tests in the early diagnosis of Alzheimer’s Disease. Featured Research Symposium on the Operationalization of the new criteria for Alzheimer’s Disease for pharmaceutical trials. Presented at the International Conference on Alzheimer’s Disease, Vienna, Austria. (Alzheimer’s & Dementia, 5[4 Suppl1], p99). 

Jacova, C., Kandiah, N., Schulzer, M., & Feldman, H. H. (2008, July). Quality of life in mild cognitive impairment that does not progress to Alzheimer Disease: Longitudinal analyses of the InDDEx study. Presented at the International Conference on Alzheimer’s Disease, Chicago, Ill. (Alzheimer’s & Dementia, 4[4 Suppl 1], T646-7).

Office Location: 
Creighton Hall 295