Claudia Jacova, PhD

Email Address: 
Phone Number: 
503-352-3613
UC Box: 
A-191

Roles and Interests

Instructor for Statistics, Research Design, Cognition & Emotion, and Biological Bases of Behavior

Supervision of PhD dissertation research projects

Research interests: aging, cognitive impairment and dementia; early cognitive and functional MRI-based recognition of cerebrovascular and neurodegenerative disease (e.g., Lacunar infarct, Alzheimer Disease, Frontotemporal Dementia); interventions to promote quality of life in dementia; cognitive and clinical instrument development for disease recognition and monitoring; cross-cultural considerations and human-computer interactions in the context of cognitive impairment and dementia.

Education

Laurea di dottore, University of Florence, Italy, 1985

PhD, University of British Columbia, Vancouver, B.C., 2003

Professional Membership

Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART)

Recent Publications (2010-Present)

Jacova, C., Hsiung, G-Y. R., Tawankanjanachot, I., Dinelle, K., et al. (in press). Anterior brain glucose hypometabolism predates dementia in progranulin mutation carriers. Neurology

Chertkow H., Feldman H. H., Jacova C., & Massoud F. (in press). Definitions in dementia and predementia states in Alzheimer Disease and Vascular Cognitive Impairment. Alzheimer’s Research & Therapy,

Lebed, E., Jacova, C., Wang, L., & Beg, M. F. (2013). Novel surface-smoothing based local gyrification index and its use in localizing changes in cortical folding in Alzheimer’s Disease. IEEE Transactions on Medical Imaging, 32(4), 660-669. 

Juarez-Cedillo, T., Sanchez-Arenas, R., Sanchez-Garcia, S., Garcia-Pena, C., Hsiung, G. Y., Sepehry, A. A., Beattie, B. L., Jacova, C. (2012). Prevalence of Mild Cognitive Impairment (MCI) and its subtypes in the Mexican elderly population. Dementia & Geriatric Cognitive Disorders, 34(5-6), 271-281. 

Edwards, J. D., Jacova, C., Sepehry, A., Pratt, B., & Benavente, O. (2013). Domain-specific neuropsychological assessment in symptomatic lacunar stroke: A systematic review. Neurology80(3), 315-322.

Jacova, C., Pearce, L. A., Costello, R., Hart, R. G., & Benavente, O. R. (2012). Cognitive impairment in lacunar strokes: The SPS3 trial. Annals of Neurology72(3), 351-362. 

Sepehry, A. A., Lee, P. E., Hsiung, G-Y. R., Beattie, B. L., & Jacova, C. (2012). Effect of SSRIs in Alzheimer Disease with comorbid depression: A meta-analysis of cognitive and depression outcomes. Drugs & Aging29(10), 793-806. 

Sepehry, A. A., Lee, P. E., Hsiung, G-Y. R., & Jacova, C. (2012). Stay the course – is it justified? Lancet379(9812), 220.

Woodward, M., Hsiung, G-Y. R., Feldman, H., Jacova, C., & Mackenzie, I. R. (2010). Multiple pathologies in dementia are common. European Geriatric Medicine, 1(5), 259-265. 

Liu-Ambrose, T., Eng, J. J., Boyd, L. A., Jacova, C., et al. Promotion of the mind throughexercise (PROMoTE): A proof-of-concept randomized controlled trial of aerobic exercise training in older adults with vascular cognitive impairment. BMC Neurology17, 10-14. 

Woodward, M., Jacova, C., Black, S., et al. (2010). Differentiating the frontal variant of Alzheimer Disease. International Journal of Geriatric Psychiatry, 25(7), 732-738.

Dubois, B., Feldman, H., Jacova, C., et al. (2010). Revising the definition of Alzheimer’s Disease: A new lexicon. Lancet Neurology, 9(11), 1118-1127. 

Representative Conference Proceedings and Presentations

*Haddad, S., McGrenere, J., & Jacova, C. (2014, April). Interface design for older adults with varying cultural attitudes toward uncertainty. Paper presented at the 30th International Conference on Human Factors in Computing Systems, Toronto, ON. Published in Proceedings of the SIGCHI Conference on Human Factors in Computing Systems, (Chi’14), ACM Press, 1913-22.

Jacova C., Hsiung G.-Y.R., Sengdy, P., Bouchard-Kerr, P., Dinelle K., McCormick, S.,  Sossi, V., Stoessl, A. J., Feldman, H. H., & Mackenzie, I. R..(2014, October). Brain glucose metabolic abnormalities in prodromal FTD/ALS with C9ORF72 mutation. Poster presented at the 9th International Conference on Frontotemporal Dementias, Vancouver, BC.

*Dowds, E., Beg, M. F., Popuri, K., Slack, P., Sengdy, P., Rademakers, R., Wittenberg, D., Feldman, H. H., Mackenzie, I. R., & Hsiung, G.-Y. R. (2014, October). Cortical thinning in presymptomatic C9ORF72 mutation carriers without changes in cognitive domain performance. Poster presented at the 9th International Conference on Frontotemporal Dementias, Vancouver, BC.

*Dowds, E., Beg, M. F., Popuri, K., Slack, P., Sengdy, P., Rademakers, R., Wittenberg, D., Feldman, H. H., Mackenzie, I. R., & Hsiung, G.-Y. R. (2014, October). Decreased performance on cognitive domains in presymptomatic GRN mutation carriers without cortical atrophy. Poster presented at the 9th International Conference on Frontotemporal Dementias, Vancouver, BC.

*Riggs, J. Jacova, C., McGrenere, J., Hsiung, G.-Y. R., Haddad, S., Corenblith, E. F., & Zhang, K. (2014, May). Computerized cognitive testing at home: are we there yet? Poster presented at the 1st BC e-health and innovative technology showcase (BC EHITS) conference, Vancouver, BC.

Robillard, J., Illes, J., Beattie, B. L., & Jacova, C. (2014, April). Online tests for Alzheimer’s Disease: ethics needed. Poster presented at the 2014 World Congress on Brain, Behavior, and Emotions, Montreal, QC.

Small, J., Jacova, C, Butters, L, Chan, M., Saidmuradova, L., & Tse, G. (2013, October). The impact of Alzheimer’s Disease on communication: perceptions of persons with AD and their family care partners. Poster presented at the 7th Canadian Conference on Dementia, Vancouver, BC.

*Sepehry, A., Chakrabarty, T., Jacova, C., & Hsiung, G.-Y. R. (2013, July). Prevalence of depressive mood in Frontotemporal Dementia (FTD): A meta-analysis of studies from 2000 to present. Poster presented at the Alzheimer’s Association 2013 International Conference, Boston, MA. Abstract published in Alzheimer’s & Dementia 2013, 9(4), P607).

*Sepehry, A., Yang, L., Hsiung, G.-Y. R., & Jacova, C. (2013, July). Music therapy, global affect and behavior in Alzheimer's disease: A meta-analytic perspective on outcomes and on music therapy methodologies. Poster presented at the Alzheimer’s Association 2013 International Conference, Boston, MA. Abstract published in Alzheimer’s & Dementia 2013, 9(4), P665.

Robillard, J., Jacova, C., Beattie, B. L., Illes,, J. (2013, July). Scientific validity and ethics of freely accessible online tests for Alzheimer disease. Paper presented at the Alzheimer’s Association 2013 International Conference, Boston, MA.

Jacova, C., Slack, P., Hsiung, G.-Y. R., Beattie, B. L., Lee, P. E. (2013, July). Patients’ self-reports on function and cognition in Alzheimer Disease are strongly influenced by their affective states: Principal component analysis of the CLIMAT scale. Poster presented at the Alzheimer’s Association 2013 International Conference, Boston, MA.

Sepehry, A. A., Chen, P., Min, H. J., Hsiung, G-Y. R., Beattie, B. L., Lee, P. E., & Jacova, C. (2013, March) Depression of AD: An evidence-based epidemiological systematic review on prevalence and symptoms. Presented at the American Academy of Neurology 65th Annual Meeting, San Diego, Calif. 

Brehmer, M., McGrenere, J., Tang, C., & Jacova, C. (2012). Investigating interruptions in the context of computerized cognitive testing of older adults. In Proceedings of the 30th International Conference on Human Factors in Computing SystemsAustin, Texas (Chi’12, ACM Press 2649-2658).

Jacova, C., Hsiung, G-Y. R., DeJesus Hernandez, M., et al. (2012, September). Presymptomatic C9ORF72 mutation carriers show a diffuse pattern of glucose metabolic reductions on (18)F-FDG-PET imaging. Presented at the 8th International Conference on Frontotemporal Dementia, Manchester, UK. (Dementia & Geriatric Cognitive Disorders, 34Suppl 1), 158.

Wang, B. W., Lu, E., Mackenzie, I. R. A., Assaly, M., Jacova, C., Lee, P. E., Beattie, B. L., & Hsiung, G-Y. R. (2012). Frequency and presentation of multiple pathology in patients enrolled in Alzheimer clinical trials. Presented at the 64th Annual Meeting of the American Academy of Neurology, New Orleans, LA.

Jacova, C., Le Huray, S., Feldman, S., et al. (2012). Sensitivity of a computerized test to aphasia: The sentence production subtest from Cognitive Testing on Computer (C-TOC).Presented at the Alzheimer’s Association International Conference, Vancouver, B.C. (Alzheimer’s & DementiaSuppl 8(5), 539-540).

Jacova, C., McGrenere, J., Lee, H., et al. Cognitive testing on computer (C-TOC): Development and validation of a novel computerized testing tool for office and home administration. Presented at the Alzheimer’s Association International Conference, Vancouver, B.C. (Alzheimer’s & Dementia, Suppl 8(5), 540). 

Sepehry, A. A., Ory, J., Yang, L., & Jacova, C. (2011, October). Music therapy and global cognitive change as a function of methodological variables: A systematic review. Presented at the 6th Canadian Conference on Dementia, Toronto, ON.

Jacova, C., Slack P., Ory J., et al. (2011, July). An fMRI study of music familiarity and brain activation in Alzheimer Disease. Poster presented at the Alzheimer’s Association International Conference, Paris, France (Alzheimer’s & Dementia, 7[4 Suppl], S248).

Jacova, C. (2011, March). The ADTI CLIMAT study. Presented at the 26th International Conference of Alzheimer’s Disease International Alzheimer’s Disease International, Toronto, ON.

Limsoontarakul, S., Jacova, C., Hsiung, G-Y. R., et al. (2011, June). fMRI activation during matrix reasoning tasks in presymptomatic FTD. Presented at the Canadian Neurological Sciences Federation, Vancouver, B.C. (Canadian Journal of Neurological Sciences39(3), Suppl 1, S52).

Hallam, B., Jacova, C., Sengdy, P., et al. (2010). Neuropsychological characteristics of presymptomatic, progranulin mutation carriers in the UBC frontotemporal lobar degeneration cohort. Presented at the 7th International Conference on Frontotemporal Dementias, Indianapolis, IN. (Dementia & Geriatric Cognitive Disorders, 30, Supplement 1, 85).

Tawankanjanachot, I., Jacova, C., Hsiung, G. Y. R., et al. (2010, October). Anterior and subcortical glucose hypometabolic rate in presymptomatic progranulin carriers. Poster at the 7th International Conference on Frontotemporal Dementias, Indianapolis. (Dementia & Geriatric Cognitive Disorders 30, Supplement 1, 82). 

Jacova, C., Lee, H. S., & Le Huray, S., et al. (2010, July). Cognitive Testing on Computer (C-TOC): Designing a computerized test battery for evaluation of cognitive impairment with user and community health professional input. Presented at the International Conference on Alzheimer’s Disease, Honolulu, Hawai‘i. (Alzheimer’s & Dementia, 6[4 Suppl 1], S317-18).

Office Location: 
HPC 2 Room 295