Chemistry Department:Roxana Ciochina

 

Assistant Professor

Chemistry Office: Murdock 108

Phone:(503) 352-1476

FAX: (503) 352-2933

E-Mail: rciochina@pacificu.edu

 

Education

  Ph.D. Chemistry, University of Kentucky, (2006)

  MS Chemistry , Natural Products, "Gh. Asachi" Technical University, Department of
     Industrial Chemistry, Iasi, Romania, (1998)

  B.S. BioChemical Engineering, "Gh, Asachi" Technical University, Department of        
     Industrial   Chemistry, Iasi, Romania, (1997)
 
 

Courses

 

 

 

Chem 220 General Chemistry I

Chem 300 Fundamentals of Organic Chemistry

Chem 400 Advanced Organic Chemistry

 

Research Interests

 

 

Current projects:

 

Research Project 1: Our group developed a series of curcumin derivatives and is currently looking into their antioxidant properties as well as antimicrobial, anti-inflammatory, and carcinogenic properties. Some curcumin derivatives showed a strong fluorescence and we have already started looking into their optical properties and their potential uses as fluorescent dyes in biomedical research.

 

Research Project 2: The objective of this project is to synthesize laurenditerpenol by using the Diels – Alder reaction in the key steps of the synthesis. Laurenditerpenol is a natural product that potentially inhibits HIF-1, a key factor in cancer progression. Students will have the chance to explore a wide variety of organic reactions, almost all studied in their sophomore courses, with a main focus on the Diels – Alder reaction. Chemical synthesis (the discipline associated with building molecular structures) is the common element that will underlie our research endeavors. Because synthesis is an integral part of the drug development process, this area of research is at the cutting edge of molecular based therapeutics. Students in our group will learn how to apply the tools of organic chemistry to important problems that span the traditional disciplines.

 

Research Project 3: This project is in collaboration with Dr. Daniela Andrei from Dominican University, River Forest, IL. The objective of this project is to develop a method for the synthesis of multisubstituted halogenated olefins via cross coupling of dihalolkenes with alkylzinc bromides (Negishi reaction). These olefins will be further used by Dr. Andrei in the synthesis of S-adenosylhomocysteine, an aminoacid derivative used in several metabolic pathways.

 

Recent Publications: