Roxana Ciochina

Roxana Ciochina

Assistant Professor, Chemistry

503-352-1476

rciochina@pacificu.edu

UC Box: A121

Office: Murdock 108

Education

PhD in Chemistry, University of Kentucky, Lexington, KY in 2006.

Master of Science in Chemistry, Natural Products, "Gh Asachi" Technical University, Department of Industrial Chemistry, Iasi, Romania in 1998.

Bachelor of Science in BioChemical Engineering, "Gh Asachi" Technical University, Department of Industrial Chemistry, Iasi, Romania in 1997.

Research Interests

      • Natural products synthesis
      • Structure-Activity Relationship (SAR) studies of antioxidant agents
      • Organic methodology

Current projects:

 

Research Project 1: Our group developed a series of curcumin derivatives and is currently looking into their antioxidant properties as well as antimicrobial, anti-inflammatory, and carcinogenic properties. Some curcumin derivatives showed a strong fluorescence and we have already started looking into their optical properties and their potential uses as fluorescent dyes in biomedical research.

 

Research Project 2: The objective of this project is to synthesize laurenditerpenol by using the Diels – Alder reaction in the key steps of the synthesis. Laurenditerpenol is a natural product that potentially inhibits HIF-1, a key factor in cancer progression. Students will have the chance to explore a wide variety of organic reactions, almost all studied in their sophomore courses, with a main focus on the Diels – Alder reaction. Chemical synthesis (the discipline associated with building molecular structures) is the common element that will underlie our research endeavors. Because synthesis is an integral part of the drug development process, this area of research is at the cutting edge of molecular based therapeutics. Students in our group will learn how to apply the tools of organic chemistry to important problems that span the traditional disciplines.

 

Research Project 3: This project is in collaboration with Dr. Daniela Andrei from Dominican University, River Forest, IL. The objective of this project is to develop a method for the synthesis of multisubstituted halogenated olefins via cross coupling of dihalolkenes with alkylzinc bromides (Negishi reaction). These olefins will be further used by Dr. Andrei in the synthesis of S-adenosylhomocysteine, an aminoacid derivative used in several metabolic pathways.

Published Works

Course Information

At Pacific University, all faculty teach a variety of different courses. Typically, we do not use graduate teaching assistants, which means that your classes will be taught by professors and that you will have plenty of opportunites to get to know the faculty in your discipline.

Below I have listed some of the courses that I teach. We are always developing and trying out new classes, so the list may change now and then. You can use the links to the left to read descriptions of the courses listed below.

 

CHEM 220 General Chemistry I

CHEM 300 Fundamentals of Organic Chemistry

CHEM 400 Advanced Organic Chemistry