Phrm Sci: Immunology & Toxicology

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This block builds on the basic principles of cellular and molecular immunology taught in PRHM 568 and emphasizes the pathophysiology of leukocytes and addresses the interaction and mechanisms of activation of the innate and adaptive immune systems. The major drug classes and agents used clinically for the treatment of immunologic disorders are introduced together with pertinent chemical properties/structure-activity relationships, and pharmacology including: mechanism of action, drug action, adverse effects, key differentiation factors between individual agents, contraindications, and clinically significant drug-drug and drug-disease interactions. In addition, toxicology, mechanisms of toxicity, the pharmacologic use of antidotes, and hepatology, particularly toxic responses of the liver and diagnostic indicators, are discussed. 2.5 credits.

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