Administration & Faculty

Aleksandar Todorovic, DPharm, PhD

Post-Graduate Instructor

Academic Fellow

503-352-7362

atodorovic@pacificu.edu

 

Education

2006 Doctor of Philosophy,
Medicinal Chemistry,
University of Florida,
Gainesville, Florida

2001 Dipl.Pharm.

University of Belgrade,

Faculty of Pharmacy,
Belgrade, Serbia

 

Areas of Research & Specialization

 

Publications (* indicates first co-author)

Todorovic A, Karljikovic-Rajic K, Agbaba D, Vukicevic- Nikolic D, Riley TN, Different Approaches in Pharmaceutical Education: Comparison of Three Educational Models, Pharm.Ed., 2 209-212 (2002)

Todorovic A, Holder JR, Scott JW, Haskell- Luevano C, Synthesis and activity of the melanocortin Xaa-d-Phe-Arg-Trp-NH tetrapeptides with amide bond modifications, J.Pep. Res., 63, 270-278 (2004)

Irani BG, Holder JR, Todorovic A, Wilczynski AM, Joseph CG, Wilson KR, Haskell-Luevano C, Progress in the development of melanocortin receptor selective ligands, Curr. Pharm. Des., 10, 3443-3479 (2004)

Haskell-Luevano C, Todorovic A, Gridley K, Sorenson N, Irani B, Xiang Z, The melanocortin pathway: effects of voluntary exercise on the melanocortin-4 receptor knockout mice and ACTH(1-24) ligand structure activity relationships at the melanocortin-2 receptor, Endocr. Res., 30, 591-597 (2004)

Todorovic A, Holder JR, Bauzo RM, Scott JW, Haskell- Luevano C,  Long chain fatty acid (LCFA) N-acyl derivatives of melanocortin X-His-DPhe-Arg-Trp-NH2 tetrapeptides: potency and selectivity alteration at mMCR system, Peptide Revolution: Genomic, Proteomics & Therapeutics, Proceeding of the 18th American Peptide Symposium, (Chorev M. and Sawyer TK, Editors), Kluwer Academic Publishers, the Netherlands, 641-642, (2004)

Todorovic A, Holder JR, Bauzo RM, Scott JW, Kavanagh R, Abdel-Malek Z, Haskell- Luevano C, N-terminal fatty acylated His-dPhe-Arg-Trp-NH(2) tetrapeptides: influence of fatty acid chain length on potency and selectivity at the mouse melanocortin receptors and human melanocytes, J. Med. Chem., 48, 3328-3336 (2005)

Todorovic A and Haskell- Luevano C, A review of melanocortin receptor small molecule ligands, Peptides, 26, 2026-2036 (2005)

Irani BG, Holder JR, Todorovic A, Wilczynski AM, Joseph CG, Wilson KR, Haskell-Luevano C, Development of melanocortin receptor selective ligands, Front Med. Chem., 3, 285-334 (2006)

Abdel-Malek ZA, Kadekaro AL, Kavanagh RJ, Todorovic A, Koikov LN, McNulty JC, Jackson PJ, Millhauser GL, Schwemberger S, Babcock G, Haskell-Luevano C, Knittel JJ, Melanoma prevention strategy based on using tetrapeptide alpha-MSH analogs that protect human melanocytes from UV-induced DNA damage and cytotoxicity, FASEB J., 20, 1561-1563 (2006)

Wilson KR, Todorovic A, Proneth B amd Haskell-Luevano C, Overview of endogenous and synthetic melanocortin peptides, Cell. Mol. Biol.,52, issue 2, 3-20 (2006)

Todorovic A, Joseph CG, Sorensen NB, Wood MS and Haskell-Luevano C, Structure-activity relationships of melanocortin agonists containing the benzimidazole scaffold. Chem. Bio. Drug Des. 69 (5),338-349 (2007)

Cai Q, Todorovic A*, Andaya A, Gao J, Leary JA and Cate JHD,  Distinct regions of human eIF3 are sufficient for binding to the HCV IRES and the 40S ribosomal subunit. J. Mol. Biol. 403, 185-196 (2010)

Sun C, Todorovic A*, Audi JQ, Bai Y, Villa N, Snyder M, Aschyan J, Lewis CS, Hartland A, Gradia S, Fraser CS, Doudna JA, Nogales E and Cate JHD Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3), Proc. Natl. Acad. Sci. U.S.A. 108 (51), 20473-20478 (2011)


J├Ąger S, Cimermancic P, Gulbahce N, Johnson JR, McGovern KE, Clarke SC, Shales M, Mercenne G, Pache L, Li K, Hernandez H, Jang GM, Roth SL, Akiva E, Marlett J, Stephens M, D'Orso I, Fernandes J, Fahey M, Mahon C, O'Donoghue AJ, Todorovic A, Morris JH, Maltby DA, Alber T, Cagney G, Bushman FD, Young JA, Chanda SK, Sundquist WI, Kortemme T, Hernandez RD, Craik CS, Burlingame A, Sali A, Frankel AD, Krogan NJ, Global landscape of HIV-human protein complexes, Nature doi: 10.1038/nature10719. (2011)

 

 

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