Administration & Faculty
Fawzy A. Elbarbry, PhD
Assistant Professor
503-352-7356
fawzy.elbarbry@pacificu.edu
Education
2006 Postdoctoral Fellow
Dept. of Medicine,
University of Saskatchewan, Canada
2006 Doctor of Philosophy,
Pharmacy, Drug Metabolism,
and Pharmacokinetics,
University of Saskatchewan, Canada
2002 Master of Science,
Analytical Chemistry,
College of Pharmacy,
University of Tanta, Egypt
1995 Postgraduate Diploma,
Analytical Chemistry,
College of Pharmacy,
University of Tanta, Egypt
1993 Bachelor of Pharmaceutical Sciences,
College of Pharmacy,
University of Tanta, Egypt
Areas of Research & Specialization
My research interests revolve around minimizing toxicity and/or drug interactions of xenobiotics through better understanding of their effect on drug metabolizing enzymes (DME), especially Cytochrome P450 (CYP) enzymes. Although CYP enzymes normally generate metabolites with diminished biological activity, there are numerous examples where these enzymes mediate the formation of reactive intermediates from chemically inert agents. These reactive metabolites play a key step in initiating cellular damage and cancers. Modification of the activity or expression level of CYP enzymes through exposure to environmental toxins, drugs, or even herbal remedies could potentially affect the clinical outcome of concomitantly-administered drugs. My research interest focuses on identifying the role of CYP enzymes in toxicity induced by drugs, herbal remedies and environmental toxins. Along with the mission of Pacific University and the School of Pharmacy, the outcome of this research will be utilized to advance the level of pharmaceutical care within the community and improve health care literacy among patients.
Publications
Book Chapters
Elbarbry F. Introduction to Toxicology. In: Karimi R, editor. Biomedical and Pharmaceutical Sciences with Patient Care Correlations. 2012 (in progress)
Elbarbry F and Karimi R. Introduction to Pharmacokinetics. In: Karimi R, editor. Biomedical and Pharmaceutical Sciences with Patient Care Correlations. 2012 (in progress)
Journal Articles
Ahmed H, Elbarbry F, Clark B. Mixed Micellar Electrokinetic Chromatographic Analysis of Colistin, a Polypeptide Antibiotic, Using Laser-Induced Fluorescence Detection. AJAC. 3:233-241. 2012
Elbarbry F, Ragheb A, Marfleet T, and Shoker A. Modulation of Hepatic Drug Metabolizing Enzymes by Dietary Doses of Thymoquinone in Female New Zealand White Rabbits. Phytotherapy Research. 2012
Karimi R, Elbarbry F, Fortner J. Integrative Student Learning: An Effective Team Learning Activity in a Learner-Centered Paradigm. Innovations in Pharmacy. 2(4):1-16. 2011
Elbarbry F and Elrody N. Potential Health Benefits of Sulforaphane: A Review of the Experimental, Clinical and Epidemiological Evidences and Underlying Mechanisms. JMPR. 5(4): 473-484. 2011
Elbarbry F, Chibbar R, Marfleet T, and Shoker A. Cyclosporine-induced changes in drug metabolizing enzymes in hyperlipemic rabbit kidneys could explain its toxicity. Xenobiotica. 40(11):772-81. 2011
Karimi R, Arendt C, Elbarbry F, Roberts S. Learning bridge: curricular integration of didactic and experiential education. AJPE. 74(3): article 48. 2010
Ragheb A, Attia A, Elbarbry F, Prasad K, Shoker A. Attenuated combined action of cyclosporine a and hyperlipidemia on atherogenesis in rabbits by thymoquinone. Evid Based Complement Alternat. Med. 2010
Elbarbry F, Attia A, Shoker A. Validation of a new HPLC method for determination of midazolam and its metabolites: application to determine its pharmacokinetics in human and measure hepatic CYP3A activity in rabbits. J Pharm Biomed Anal. 50(5):987-93. 2009
Ragheb A, Attia A, Elbarbry F, Shoker A. The protective effect of thymoquinone, an anti-oxidant and anti-inflammatory agent, against renal injury: a review. SJKDT. 20(5): 741-752. 2009
Elbarbry F and Alcorn J. Ontogeny of glutathione and glutathione-related antioxidant enzymes in rat liver. Research in Veterinary Sciences. 87(2):242-244. 2009
Ragheb A, Elbarbry F, Prasad K, Mohammed A, Shoker A. Attenuation of the development of hypercholesterolemic atherosclerosis by thymoquinone. Int. J. Angiol. 17(4):186-192. 2008
Elbarbry F, Marfleet T, and Shoker A. Drug-drug interactions with immunosuppressive agents: review of the in vitro functional assays and role of cytochrome P450 enzymes. Transplantation. 85(9), 1222-1229. 2008
Elbarbry F and Shoker A. Liquid chromatographic determination of mycophenolic acid and its metabolites in human kidney transplant plasma: pharmacokinetic application. J Chromatogr. B. 859(2):276-81. 2007
Elbarbry F and Shoker A. Therapeutic drug measurement of mycophenolic acid derivatives in transplant patients. Clinical Biochemistry. 40(11):752-64. 2007
Elbarbry F, McNamara P, and Alcorn J. Ontogeny of hepatic CYP1A2 and CYP2E1 expression in rat. J Biochem. Mol Toxicol. 21(1):41-50. 2007
Elbarbry F, Eldawy M, Mabrouk M. Determination of the analgesic components of Spasmomigraine tablet by liquid chromatography with ultraviolet detection. J AOAC Int. 90(1): 94-101. 2007
Alcorn J, Elbarbry F, and McNamara P. Evaluation of the assumptions of an ontogeny model of rat hepatic cytochrome P450 activity. Drug Metabolism and Disposition. 35(12):2225-31. 2007
Elbarbry F and Shoker A. Simple high performance liquid chromatographic assay for mycophenolic acid in renal transplant patients. J Pharm. Biomed Anal. 43(2): 788-92. 2007
Elbarbry F, Wilby K, and Alcorn J. Validation of a HPLC method for the determination of p-nitrophenol hydroxylase activity in rat hepatic microsomes. J Chromatogr. B. 834 (1-2): 199-203. 2006
Elbarbry F and Alcorn J. Maturation of Cytochrome P450 2E1 and Glutathione-S-Transferases, Pharmacokinetic Model Validation, J Pharm. Pharmaceutical Sci., 7(2): 284-302. 2004
Eldawy M, Mabrouk M, and El-barbary F. Determination of chlorpheniramine maleate and tincture ipecac in dosage form by liquid chromatography with ultraviolet detection. J AOAC Int. 86 (4): 675-80. 2003
Eldawy M, Mabrouk M, and El-barbary F. Liquid chromatographic determination of fluoxetine. J Pharm Biomed Anal. 30 (3), 561-71. 2002