Photo of Fawzy Elbarbry

Fawzy A. Elbarbry, BSPharm, MSPharm, PhD, RPh

Associate Professor
503-352-7356
Health Professions Building 2 370
Areas I Teach: 

Teaching

PHRM 562 | Pharmacodynamics and Pharmacokinetics Interface

PHRM 581| Endocrine (Diabetes)

PHRM 582| Hematology/Oncology (Anticoagulants)

PHRM 585 | Pharmacokinetics

PHRM 681 | Infectious Diseases

PHRM 684 | Critical Care

CHP599 | Diving Deep into Diabetes

Education

2010 | Foreign Pharmacy Graduate Examination Certificate (FPGEC), National Association of Boards of Pharmacy

2006 | Postdoctoral Fellow, Department of Medicine, University of Saskatchewan, Canada

2006 | Doctor of Philosophy, Pharmacy, Drug Metabolism, and Pharmacokinetics, University of Saskatchewan, Canada

2002 | Master of Science, Analytical Chemistry, College of Pharmacy, University of Tanta, Egypt

1995 | Postgraduate Diploma, Analytical Chemistry, College of Pharmacy, University of Tanta, Egypt

1993 | Bachelor of Pharmaceutical Sciences, College of Pharmacy, University of Tanta, Egypt

Areas of Research & Specialization

My research interests revolve around minimizing toxicity and/or drug interactions of xenobiotics through better understanding of their effect on drug metabolizing enzymes (DME), especially Cytochrome P450 (CYP) enzymes.  Although CYP enzymes normally generate metabolites with diminished biological activity, there are numerous examples where these enzymes mediate the formation of reactive intermediates from chemically inert agents.  These reactive metabolites play a key step in initiating cellular damage and cancers.  Modification of the activity or expression level of CYP enzymes through exposure to environmental toxins, drugs, or even herbal remedies could potentially affect the clinical outcome of concomitantly-administered drugs.  My research interest focuses on identifying the role of CYP enzymes in toxicity induced by drugs, herbal remedies and environmental toxins.  Along with the mission of Pacific University and the School of Pharmacy, the outcome of this research will be utilized to advance the level of pharmaceutical care within the community and improve health care literacy among patients.  The following projects are being conducted in our research facility in HPC2 and/or in collaboration with scientists from Oregon Health and Science University and University of Saskatchewan (Canada).

Project 1: Studying the Effect of Herbal Remedies on Drug Metabolizing Enzymes

Several animal studies (e.g. those of my postdoctoral research) and human clinical trials have demonstrated that consumption of some natural products decreases morbidity associated with chronic disease.  Therefore, public consumption of these products is expected to increase.  As a pharmacist, I find the increased use of natural products and nutraceuticals without consultation from the physician or pharmacist is concerning. Therefore in order to provide evidence-based consultation, more understanding of how these products (and their metabolites) affect the activity of drug metabolizing enzymes (DME) is needed.  This research focuses on filling this need by studying the bidirectional relationship between natural products and physiological systems. Induction or inhibition of DME by natural products can potentially affect bioavailability, and consequently, toxic effect of concomitantly administered medications. 

Project 2: Studying the Effect of Herbal Remedies on Arachidonic Acid Metabolism as a Target for Hypertension Treatment

Substantial evidences indicate that metabolites of Arachidonic acid (AA) via kidney Cytochrome P450 (CYP) enzymes play a critical role in regulation of renal vascular tone, sodium transport, and may participate in the pathogenesis of hypertension.  20-hydroxyeicosatetraenoic acid (20-HETE) is one of the major AA products of CYP metabolism in the kidney.  In the renal and peripheral vasculature, 20-HETE is a potent vasoconstrictor that acts by depolarizing the vascular smooth muscles (VSM) cells.  Several studies have shown that the vasoconstriction response to vasoconstrictor agonists such as angiotensin II and norepinephrin is secondary to stimulating the endogenous production of 20-HETE in renal VSM cells.  In the rat; CYP4A1, CYP4A2 and CYP4A3 were found to exhibit the highest catalytic activity for the formation of 20-HETE. Therefore, specific inhibition of these CYP enzymes could be a potential target for prevention and/or treatment of hypertension mediated by elevation of 20-HETE formation.  Our lab is currently investigating the antihypertensive potential of Sulforaphane, the main active ingredient of broccoli sprouts and cruciferous vegetables.  We will investigate the potential inhibitory effect of Sulforaphane (SF) on the activity and expression of CYP enzymes involved in 20-HETE formation.

Selected Publications and Presentations

(* indicates student co-authors)

Peer-Reviewed Journal Articles

  1. Elbarbry F.  Vancomycin Dosing and Monitoring:  Critical Evaluation of the Current Practice. Eur J Drug Metab Pharmacokinet. 2018. In-Press
  2. Ung A*, Abdelkawy K., Elbarbry F.  Studying the Inhibitory Effect of Quercetin and Thymoquinone on Human Cytochrome P450 Enzyme Activities. Pharmacognosy Magazine. 2018. In-Press
  3. Hughes J, Cleven A, Ross J, Fuentes D, Elbarbry F, Suzuki M, Della Paolera M, Carter N, Stamper B, Low P, Malhotra A, Faro S. A Comprehensive Reflective Journal-Writing Framework for Students to See their Experiences through Diverse Lenses and Develop Actionable Goals.  Am J Pharm Educ. 2017. 
  4. Stamper B, Buhler A, Harrelson J, Roberts S, Malhotra A, Elbarbry F, Rao D, Karimi R, Turner R, Marlow C, Devaud L. Forecasting academic success through implementation of an online prerequisite review tutorials program for first year pharmacy students. Curr Pharm Teach Learn 2017 9(2): 261.
  5. Abdelkawy K., Elbarbry F.  (-)-Epictaechin; A Plant Arginase Inhibitor with Favorable Pharmacokinetic Profile. Ann Clin Exp Hypertension. 2017 5(1): 1044.
  6. Abdelkawy K., Kelsey Lack*., Elbarbry F.  Pharmacokinetics and Pharmacodynamics of Promising Arginase Inhibitors. Eur J Drug Metab Pharmacokinet. 2017  42(3):355.
  7. Abdelkawy K, Balyshev ME*, Elbarbry F. A New Validated HPLC Method for the Determination of Quercetin: Application to Study Pharmacokinetics in Rats.  Biomed Chromatogr. 2017 31(3):19.
  8. Tran M*, Elbarbry F. Influence of Diabetes Mellitus on Pharmacokinetics of Drugs. MOJ Bioequiv 2016 2(1): 00016. DOI: 10.15406/mojbb.2016.02.00016.
  9. Abdelkawy K, Donia A*, Turner B, Elbarbry F. Effects of Lemon and Seville Orange Juices on the Pharmacokinetic Properties of Sildenafil in Healthy Subjects. Drugs R D 2016  16(3):271-278
  10. Abdelkawy K, Donia A*, Elbarbry F. Effects of Grapefruit Juice and Pomegranate Juice on the Pharmacokinetics of Dapoxetine and Midazolam in Healthy Volunteers.  Eur J Drug Metab Pharmacokinet. 2016 DOI: 10.1007/s13318-016-0352-3.
  11. Chan J, Oshiro T, Thomas S, Higa A*, Black S, Todorovic A, Elbarbry F, Harrelson JP.  Inactivation of CYP2A6 by the Dietary Phenylpropanoid trans-Cinnamic Aldehyde (Cinnamaldehyde) and Estimation of Interactions with Nicotine and Letrozole. Drug Metab Dispos. 2016  44(4): 534-43.
  12. Ong C*, Elbarbry F.  A New Validated HPLC Method for the Determination of Sulforaphane: Application to Study Pharmacokinetics of Sulforaphane in Rats. Biomed Chromatogr. 2016 30(7): 1016-1021.
  13. Turner B, Rouse S, Elbarbry F, Wanek S, Grover V, Chang E.  Azithromycin pharmacokinetics in adults with acute respiratory distress syndrome undergoing treatment with extracorporeal-membrane oxygenation. Ann Pharmacother. 2016 50(1): 72.
  14. Turner B, Biondo L, Elbarbry F.  Pharmacokinetics of once and twice daily dosing of intravenous tobramycin in pediatric patients with cystic fibrosis.  J Chemother. 2016 28(4):304.
  15. Elbarbry F.  Oral Bioavailability in Special Populations. MOJ Bioequiv Availab. 2015 1(3): 00012. DOI: 10.15406/mojbb.2015.01.00012.
  16. Elbarbry F, Rao D, Vermehren Schmaedick  A. Modulation of Arachidonic Acid Metabolism in the Rat Kidney by Resveratrol: Implications for Regulation of Blood Pressure. Pharmacologia. 2015 DOI: 10.5567/pharmacologia.2015.360.370.
  17. Bath S*, Hytham A, Ebeid W*, Elbarbry F.  Development and Validation of a New Simple Liquid Chromatographic Method for Determination of Coumarin and its 7-Hydroxy Metabolite as a Marker of Cytochrome P450 2A6 in Rats.  J App Pharm Sci. 2015 5(07): 130-135.
  18. Amin A*, Can Gongora M*, Elbarbry F. Dietary Doses of Sulforaphane Affect Hepatic Drug Metabolizing Enzymes in Spontaneously Hypertensive Rats.  Phytother Res. 2015 18. doi: 10.1002/ptr.5397.
  19. Malhotra A, Bath S*, Elbarbry F. An Organ System Approach to Explore the Antioxidative, Anti-Inflammatory, and Cytoprotective Actions of Resveratrol. Oxid Med Cell Longev. 2015 2015: 803971.
  20. Ebeid W*, Ahmed H, Elbarbry F. Production and analysis of a biosimilar erythropoietin in Egypt. Biosimilars. 2014 4: 11–22.
  21. Elbarbry F, Vermehren Schmaedick  A, Balkowiec A. Modulation of Arachidonic Acid Metabolism in the Rat Kidney by Sulforaphane: Implications for Regulation of Blood Pressure. ISRN-Pharmacol.   2014 2014: 683508.

Books

  1. Elbarbry F.  ABCs of Pharmacokinetics. CreateSpace 2018.

Book Chapters

  1. Shatnawi A, Shafer A, Ahmed H, Elbarbry F. Complementary and Alternative Medicine Use in Hypertension: The Good, the Bad, and the Ugly: Hypertension Treatment From Nature – Myth or Fact?. In: Malhotra A, Editor. Emerging Applications, Perspectives, and Discoveries in Cardiovascular Research. 2017.
  2. Elbarbry F. Introduction to Toxicology. In: Karimi R, editor.  Biomedical and Pharmaceutical Sciences with Patient Care Correlations. Jones & Bartlett 2014.
  3. Karimi R, Elbarbry F. Introduction to Pharmacokinetics. In: Karimi R, editor.  Biomedical and Pharmaceutical Sciences with Patient Care Correlations. Jones & Bartlett 2014.

Non-Peer Reviewed Journal Articles

  1. Elbarbry F. Paris Attacks; Random thoughts from a Muslim Educator at Pacific University. In: Pacific magazine. 2016.

Platform Presentations

  1. Elbarbry F.  “Science- Practice Connect”- In-Class Activities to Connect Basic Science and Clinical Practice Concepts Across Didactic-Years.  American Association of Colleges of Pharmacy Annual Meeting. Nashville, TN; July 2017.
  2. Elbarbry F.  Connecting Science to Practice in the Classroom. Pacific University College of Health Professions Seminar, Hillsboro, OR; April 2017.
  3. Elbarbry F. Keynote Session: Modulation of Drug Metabolizing Enzymes by Dietary Doses of Sulforaphane; Role in its Anti-hypertensive and Anti-oxidant Effect in Spontaneously Hypertensive Rats.  7th Euro-Global Summit on Toxicology and Applied Pharmacology, Rome, Italy; October 2016.
  4. Karimi R, Bradley B, Della Paolera MA, Elbarbry F, Stamper BD, Fuentes D. Mini Session: Building a Shared Governance to Promote Trust, Transparency, and Collegiality among Administration, Faculty, and Staff. American Association of Colleges of Pharmacy Annual Meeting, Anaheim, CA; July 2016.
  5. Elbarbry F. How to implement active learning strategies to enhance students’ retention, application and integration skills.  American Association of Colleges of Pharmacy Annual Meeting, Anaheim, CA; July 2016.
  6. Fuentes D,  Williams E, Hughes J, Faro S, Suzuki M, Shwartz J, Elbarbry F. A Longitudinal Pharmacotherapy Self-Assessment Series to Help APPE Students Review Didactic and Curricular Content. American Association of Colleges of Pharmacy Annual Meeting, Anaheim, CA; July 2016.
  7. Elbarbry F. Pharmacokinetics of Vancomycin; From Science to Practice. Oregon Society of Health-Systems Pharmacists (OSHP), Sunriver, OR; April 2016
  8. Elbarbry F.  Clinical Pharmacokinetics of Vancomycin. Legacy Health System, Salmon Creek, WA; November 2015.
  9. Elbarbry F. Best Research Paper: Modulation of Hepatic Drug Metabolizing Enzymes in Spontaneously Hypertensive Rats by Dietary Doses of  Sulforaphane.  The 3rd Annual International Conference on Pharmacology and Pharmacological Sciences (PHARMA 2015), Bangkok, Thailand; October 2015.
  10. Doyle I, Elbarbry F, Markus K, Marlow C, Fuentes D. Mini Session: Mapping Exam Questions to Curricular Outcomes. American Association of Colleges of Pharmacy Annual Meeting, National Harbor, MD; July 2015.
  11. Elbarbry F. Best Research Paper: Modulation of Arachidonic Acid Metabolism,  A potential Target for Hypertension Treatment.  The 1st Annual International Conference on Pharmacology and Pharmacological Sciences (PHARMA 2015), Singapore; October 2013.

Poster Presentations

  1. Pham T*, Ibrahim K, Espiritu M, Harrelson J, Elbarbry F.  Exploration of Quercetin Effects on Arachidonic Acid Metabolism and Arterial Blood Pressure using Liquid Chromatography-Mass Spectrometry/Mass Spectrometry.  ASHP Midyear 2017 Clinical Meeting and Exhibition, Orlando FL; Dec. 2017.
  2. Roberts S, Malhotra A, Harrelson H, Devaud L, Stamper B, Elbarbry F, Rao R, Buhler A, Carter N, Karimi R. Enhancing pharmacy student engagement in pharmaceutical research.  American Association of Colleges of Pharmacy Annual Meeting, Nashville, TN; July 2017.
  3. Ung A*, Vo M*, Elbarbry F. Studying the Inhibitory Effect of Quercetin and Thymoquinone on Human Cytochrome P450 Enzyme Activities.  American Association of Colleges of Pharmacy Annual Meeting, Nashville, TN; July 2017.
  4. Plechot K*, Wilson E*, Turner B, Elbarbry F. Pharmacokinetic and Pharmacodynamic Properties of Vancomycin in Various Pediatric Populations. Oregon Society of Health-System Pharmacists (OSHP) Annual Seminar, Gleneden Beach, OR; April 2017 (Best Poster Award)
  5. Ung A*, Vo M*, Elbarbry F. Studying the Inhibitory Effect of Quercetin and Thymoquinone on Human Cytochrome P450 Enzyme Activities.  Annual CHP Poster Session, Hillsboro, OR; April 2017.
  6. Ung A*, Vo M*, Abdelkawy K, Elbarbry F. Studying the Inhibitory Effect of Quercetin and Thymoquinone on Human Cytochrome P450 Enzyme Activities.  Murdock Conference, Seattle, WA; October 2016.
  7. Can Gongora M*, Rao D, Elbarbry F. Effect of Dietary Doses of Resveratrol on Hepatic Drug Metabolizing Enzymes in Spontaneously Hypertensive Rats.  American Association of Colleges of Pharmacy Annual Meeting, Anaheim, CA; July 2016.
  8. Karimi R, Backus D, Barton R, Bradley B, Clevan A, Elbarbry F, Fortner J, Fuentes D, Hughes J, Levine E, Millard M, Marlow M, Sigrid R, Saito E, Stockmann S*.  Leading Positive Change through Effective and Inclusive Strategic Planning Initiatives.  American Association of Colleges of Pharmacy (AACP) Annual Meeting, Anaheim, CA; July 2016.  
  9. Suzuki S,  Backus D, Gibbard R,  Clevan A, Elbarbry F, Hughes J, Nuziale B, Stamper B, Faro S.  Equivalency of Faculty and Student Evaluations for Pharmacotherapy Group Presentations: Transforming Students to be Educators.  American Association of Colleges of Pharmacy (AACP) Annual Meeting, Anaheim, CA; July 2016.
  10. Bath S*., Elbarbry F.  Development and Validation of a New Simple Liquid Chromatographic Method for Determination of Coumarin and its 7-Hydroxy Metabolite as a Marker of Cytochrome P450 2A6 in Rats. AAPS National Biotechnology Conference, San Francisco, CA; Nov. 2015.  
  11. Ahmed H, Omar M*, Elbarbry F. Development and Validation of a New Chromatographic Method for Simultaneous Determination of Vitamin A and E in Pharmaceutical Preparations. 75th FIP World Congress of Pharmacy and Pharmaceutical Sciences, Düsseldorf, Germany; September 2015.
  12. Karimi R, Chavez B, Elbarbry F, Fortner F, Fuentes D, Hughes J, Millard M, Roberts S, Barton R, Marlow C.  Enhancing self-awareness through intentional linkage of student performance data and perceptions.  AACP Annual Meeting, Pharmacy EducationNational Harbor, MD; July 2015.   
  13. Fortner F, Millard M, Elbarbry F, Hughes J, Devaud L, Marlow C.  Increasing Transparency and Engagement in the ACPE Self-Study Process.  AACP Annual Meeting, Pharmacy EducationNational Harbor, MD; July 2015.
  14. Bath S*, Elbarbry F.  Development and Validation of a New Simple Liquid Chromatographic Method for Determination of Coumarin and its 7-Hydroxy Metabolite as a Marker of Cytochrome P450 2A6 in Rats. AAPS National Biotechnology Conference, San Francisco, CA; June 2015.
  15. Amin A*, Can Gongora M*, Elbarbry F. Effect of Dietary Doses of Sulforaphane on Hepatic Drug Metabolizing Enzymes in Spontaneously Hypertensive Rats.  2nd Annual CHP Poster Session, Hillsboro, OR;  March 2015.
  16. Amin A*, Can Gongora M*, Elbarbry F. Effect of Dietary Doses of Sulforaphane on Hepatic Drug Metabolizing Enzymes in Spontaneously Hypertensive Rats.  American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition,  San Diego, CA; November 2014.
  17. Vermehren-Schmaedick A, Rao D, Elbarbry F.  Modulation of Arachidonic Acid Metabolism in the Rat Kidney by Resveratrol: Implications for Regulation of Blood Pressure. American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition,  San Diego, CA; November 2014. 
  18. Chiang T*, Harrelson J, Elbarbry F, Rao D.  In-Vitro Assessment of Combination Natural Product Therapy for Cancer Treatment. American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition,  San Diego, CA; November 2014. 
  19. Stamper B, Buhler A, Harrelson J, Malhotra M Roberts S,  Elbarbry F, Rao D, Marlow C, Karimi R, Leslie L.  Development of online pharmacy prerequisites reviews tutorials for first year pharmacy students. American Association of Colleges of Pharmacy (AACP) Annual Meeting.  Grapevine, TX; July 2014.