Paige Hall Osberg, PhD

Email Address: 
Phone Number: 
UC Box: 
Office Location: 
Douglas C. Srain Science Center 107 (Forest Grove)

Course Information

At Pacific University, all faculty teach a variety of different courses. Typically, we do not use graduate teaching assistants, which means that your classes will be taught by professors and that you will have plenty of opportunities to get to know the faculty in your discipline.

Below I have listed some of the courses that I teach. We are always developing and trying out new classes, so the list may change now and then.

CHEM 220 | General Chemistry I
CHEM 370 | Fundamentals of Physical Chemistry
CHEM 450 | Materials and Nanoscience
CHEM 472 | Chemical Thermodynamics and Kinetics
CHEM 486 | Research


PhD in Physical Chemistry, Northwestern University, Evanston, IL 2010
Bachelor of Science, Biochemistry and Spanish double major, University of Notre Dame, South Bend, IN, 2005

Areas of Research & Specialization

NANOSENSORS. In my research lab we study nanoparticles made of silver and gold. These nanoparticles have incredible optical properties that make them appear colored on the nanoscale—gold nanoparticles, for example, often appear red, while silver nanoparticles are typically green. Importantly, when molecules bind to the surfaces of these nanoparticles, they change color. This property enables metallic nanoparticles to be used as sensing devices in a variety of applications.
My students are involved in projects aiming to optimize the sensitivity of gold and silver nanoparticles by carefully tailoring their size and shape. We fabricate nanoparticles using lithographic methods and instruments available at Portland State University’s Center for Electron Microscopy and Nanofabrication. Once the nanoparticles are fabricated, we investigate their sensitivity using spectroscopic techniques. Ultimately, we use these nanoparticles in detection applications, such as disease diagnosis and testing for food and water contaminants. Our goal is to create low-cost, portable sensors for real-world applications.


1. J. Ruemmele, W. P. Hall,* L. Ruvuna, R. P. Van Duyne: A Localized Surface Plasmon Resonance Imaging Instrument for Multiplexed Biosensing. Analytical Chemistry 85, 4560-4566 (2013)
2. W. P. Hall; J. Modica; Y. Lin; J. N. Anker; M. Mrksich; R. P. Van Duyne: A Conformation- and Ion-Sensitive Plasmonic Biosensor.  Nano Letters 11, 1098-1105 (2011)
3. W. P. Hall; S. Ngatia; R. P. Van Duyne: LSPR Biosensor Signal Enhancement Using Nanoparticle-Antibody Conjugates. J. Phys. Chem. C 115, 1410-1414 (2011)
4. D. E. Ashkenaz; W. P. Hall; C. L. Haynes; E. M. Hicks; A. D. McFarland; L. J. Sherry; D. A. Stuart; K. E. Wheeler; C. R. Yonzon; J. Zhao; H. A. Godwin; R. P. Van Duyne: Coffee Cup Atomic Force Microscopy. J. Chemical Education 87, 306-307 (2010)
5. J. N. Anker; W. P. Hall; M. Lambert; P. Velasco; W. Klein; R. P. Van Duyne: Detection and Identification of Bioanalytes with High Resolution LSPR Spectroscopy and MALDI Mass Spectrometry. J. Phys. Chem. C 113, 5891-5894 (2009)
6. J. N. Anker, W. P. Hall, O. Lyandres, N. C. Shah, J. Zhao, R. P. Van Duyne: Biosensing with Plasmonic Nanosensors. Nature Materials, 7, 442-453 (2008)
7. W. P. Hall; J. N. Anker; Y. Lin; J. Modica; M. Mrksich; R. P. Van Duyne:  A Calcium-Modulated Plasmonic Switch. J. Am. Chem. Soc. 130, 5836-5837 (2008)
8. A. J. Haes, W. P. Hall, L. Chang, W. L. Klein, R. P. Van Duyne: A Localized Surface Plasmon Resonance Biosensor:  First Steps Toward an Assay for Alzheimer’s Disease. Nano Letters 4, 1029-1034 (2004)
* Co-first authorship

Recent Student Posters

"Characterization of Kombucha Fermentation by Titration and HPLC,” Nicole Lawton, Sean Tachibana and W. Paige Hall, Food and Agriculture Poster session, 249th National American Chemical Society Meeting, Denver, CO March 2015

Area of Study I Teach (Undergraduate):