1502-Post-Doctorate Fellow

Job #:  1502

This position is a unique career development opportunity geared towards a candidate who has a strong interest in both teaching and research. The postdoctoral fellow will have the opportunity to learn and experience various aspects of academia, including teaching, scholarship, and service. The successful candidate will spend the majority of time conducting research that aligns with a School of Pharmacy pharmaceutical science faculty member. This is a two-year position to begin July 1, 2017.

RESPONSIBILITIES

·         Gain additional expertise in a designated research area and demonstrate a high level of productivity.

·         Provide up to 20 hours of classroom teaching per year in the PharmD curriculum in a relevant pharmaceutical sciences area.

·         Serve as a member on a School standing committee.

REQUIRED KNOWLEDGE, SKILLS AND ABILITIES:

·         A Ph.D. in a pharmaceutical or biomedical sciences-related discipline.

·         Experience in writing and submitting manuscripts and/or grant applications.

·         Excellent communication skills and an ability to work effectively as a team member in all aspects of the academic environment (research, teaching and service).

RESEARCH PROJECTS

The candidate will select a mentor and conduct research in the mentor’s area of expertise.

Available mentors and projects:

1.    Carter lab: Uses advanced molecular biology, protein chemistry, and proteomic technologies to investigate host-parasite interactions pertaining to the human pathogen Leishmania donovani. Areas of focus include the molecular characterization of membrane complexes used to facilitate nutrient capture from the host environment and the delineation of pro-survival signaling pathways and responses that enable parasite survival during nutrient starvation.

2.    Devaud lab: Explores potential neurochemical mechanisms contributing to behavioral measures in male and female animal models.  We focus on the effects of ethanol and/or stress exposure.

3.    Elbarbry lab: Minimizing toxicity and/or drug interactions of xenobiotics and herbal remedies through better understanding of their effect on drug metabolizing enzymes, especially Cytochrome P450 enzymes.  Current focus is improving our understanding of the underlying mechanisms contributing to the anti-hypertensive effects of natural products such as sulforaphane, resveratrol, and thymoquinone.

4.    Harrelson lab: We recently received funding from the National Institute on Drug Abuse to investigate how cinnamic aldehyde (CA) inhibits the major nicotine metabolizing enzyme, cytochrome P450 2A6 (CYP2A6), and to use this information to design more potent and selective inhibitors, with the goal of designing new agents to treat nicotine addiction.  The work is based on our discovery that CA, a natural product from cinnamon oil, is a selective mechanism-based inhibitor of CYP2A6.  Our team, which includes a full-time technician, is also evaluating CA and the most potent structural analogs for ‘drug-like’ characteristics, by evaluating pharmacokinetic stability and hepatotoxicity risk, two common sources of attrition during drug discovery.  We use many techniques including protein expression/purification, LC-MS and HPLC fluorescence, ligand-binding assays, molecular modeling with Autodock Vina to evaluate drug-target interactions, and in vitro-in vivo extrapolation to predict changes in pharmacokinetic parameters and drug-drug/drug-herb interactions.  Other pursuits in the lab involve an investigation of the basis of interpatient variability in letrozole metabolism (letrozole is a drug used to treat breast cancer), mechanisms of CYP allosteric regulation, and reactive metabolite formation.          

5.    Rao lab:  investigation of biocompatible and biodegradable polymers as micellar drug delivery systems for cancer therapeutics.  There is a particular focus on combining traditional chemotherapeutic agents with natural products to promote effectiveness and reduce cardiotoxicity.

6.    Stamper lab: utilization of comparative genomic and transcriptomic approaches to identify key pathways critical to propagating toxicologic outcomes.  Current projects focus on toxicogenomic approaches to investigate the differential toxicity associated with structurally similar compounds.

The applicant is encouraged to reach out to individual faculty members for more information on this position. Contact information can be found on the Pacific University School of Pharmacy website: http://www.pacificu.edu/future-graduate-professional/colleges/college-health-professions/areas-study/pharmacy?qt-undergraduate_area_of_study_qt=1#qt-undergraduate_area_of_study_qt

APPLICATION:  Applicants interested in this opportunity should submit a letter of intent, curriculum vitae, and names of three references. The letter of intent should identify the top two or three research project preferences, include a teaching philosophy, and describe career goals and how a position at Pacific University will aid these goals. Application materials will be screened and interview candidates will be selected and notified.  The position will remain open until filled.  All applicants will be notified once the position is filled.  Employment is contingent upon eligibility to work in the United States.

Submit application materials to:  Sigrid Roberts (sroberts@pacificu.edu), Chair, Postdoctoral Fellow Search Committee, Pacific University School of Pharmacy.

Applications will be accepted until December 15th, with phone interviews scheduled in December and on site interviews in January/February of 2017.

DISCOVER PACIFIC UNIVERSITY:  Pacific University is a small but diverse community, where students thrive in a personal academic environment.  Tracing its roots back to 1849, when it began as a school for orphans of the Oregon Trail, Pacific has long been devoted to making a difference in people’s lives.

Today, students study in a unique combination of undergraduate, graduate and professional programs in the liberal arts and sciences, optometry, education, health professions and business.  Pacific University has campuses in Forest Grove, Hillsboro, Eugene and Woodburn, Ore., as well as an office in Honolulu.  In addition, a variety of Pacific University health and eye clinics throughout the Portland area serve patients and provide students with practical experience.

At Pacific University, students and faculty engage in discovery through close, nurturing relationships that provide extraordinary learning experiences.  International study, service learning, internships and co-curricular activities have been integral parts of the education of nearly 25,000 alumni worldwide who share in the Boxer spirit.

NOTICE OF NONDISCRIMINATION POLICY

It is the policy of Pacific University not to discriminate on the basis of race, color, national or ethnic origin, ancestry, age, religion or religious creed, disability or handicap, sex or gender (including pregnancy, sexual harassment and other sexual misconduct including acts of sexual violence such as rape, sexual assault, sexual exploitation and coercion), gender identity and/or expression (including a transgender identity), sexual orientation, military or veteran status,  genetic information,  or any other characteristic protected under applicable federal, state or local law.  Retaliation is also prohibited.  Pacific University will comply with state and federal laws such as Title IX, Title VI and Title VII of the Civil Rights Act, the Americans with Disabilities Act, Section 504 of the Rehabilitation Act of 1973, the Age Discrimination in Employment Act, and other similar laws that prohibit discrimination.  Questions or complaints may be directed to the Vice President for Academic Affairs, 2043 College Way, Forest Grove, OR 97116, provost@pacificu.edu.