This block emphasizes the role of endocrinology and regulatory hormones in the metabolism of glucose and synthesis of thyroid and sex hormones. In addition, the pathophysiological conditions causing diabetes, thyroid and bone disorders and the mechanisms underlying contraception, infertility, and hormone replacement therapy are discussed. The major drug classes and agents used clinically for the treatment of these conditions are introduced together with pertinent chemical properties/structure-activity relationships and pharmacology including: mechanism of action, routes of administration, adverse effects, key differentiation factors between individual agents, contraindications, and clinically significant drug-drug and drug-disease interactions. After this course, students should be able to understand and describe diabetes mellitus, the effects of steroid hormones, the mechanisms of oral contraception and hormone replacement therapy, osteoporosis and osteomalacia, and hypo- and hyperthyroidism. 2.5 credits.