Dr. Andy Weyer, PT, DPT, PhD, recently published a review article on the molecular sensor of cold temperatures along with Dr. Sonya Lehto, a Senior Scientist at the pharmaceutical company Amgen.
Andy Weyer PT, DPT, PhD
DPT-520 – Rehabilitation Neuroscience I
DPT-522 – Rehabilitation Neuroscience II and Motor Control
DPT-540 – Patient Assessment, Intervention, and Therapeutic Modalities
Areas of Interest
BS, Human Biology, Marquette University, 2008
DPT, Marquette University, 2010
PhD, Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, 2015
Weyer AD and Lehto SG. Development of TRPM8 antagonists to treat chronic pain and migraine. Pharmaceuticals (Basel). 2017 Mar 30; 10(2) pii: E37
Lehto SG, Weyer AD, Youngblood BD, Zhang M, Yin R, Wang W, Teffera Y, Cooke M, Stucky CL, Schenkel L, Geuns-Meyer S, Moyer BD, Wild KD, and Gavva NR. Selective antagonism of TRPA1 produces limited efficacy in models of inflammatory- and neuropathic-induced mechanical hypersensitivity in rats. Mol. Pain. 2016 Nov 19;12 pii: 1744806916677761
Osteen JD, Herzig V, Gilchrist J, Emrick JJ, Zhang C, Wang X, Castro J, Garcia-Caraballo S, Grundy L, Rychkov GY, Weyer AD, Dekan Z, Undheim EAB, Alewood P, Stucky CL, Brierley SM, Basbaum AI, Bosmans F, King GF, and Julius D. Subtype-selective spider toxins implicate Nav1.1 voltage-gated sodium channels in mechanical pain. Nature. 2016 Jun 6;534(7608):494-9.
Zappia KJ, Garrison SR, Palygin O, Weyer AD, Barabas ME, Lawlor MW, Staruschenko A, and Stucky CL. Mechanosensory Deficits Correlate with Diminished Cutaneous ATP Release, despite Minimal Detection of TRPA1 in Mouse Keratinocytes. PLoS One. 2016 Mar 15;11(3):e0151602
Weyer AD, Zappia KJ, Garrison SR, O’Hara CL, Dodge AK, and Stucky CL. Nociceptor sensitization depends on age and pain chronicity. eNeuro. 2016 Feb 8;3(1). pii: ENEURO.0115-15.2015
Yu H, Pan B, Weyer AD, Wu HE, Meng J, Fischer G, Vilceanu D, Light A, Stucky CL, Rice F, Hudmon A, and Hogan Q. CAMKII controls whether touch is painful. The Journal of Neuroscience. 2015 Oct 21; 35(42): 14086-102.
Weyer AD, O’Hara CL, and Stucky CL. Amplified mechanically-gated currents in distinct subsets of myelinated sensory neurons following in vivo inflammation of skin and muscle. The Journal of Neuroscience. 2015 Jun 24; 35(25): 9456-62.
Weyer AD and Stucky CL. Repurposing a leukocyte elastase inhibitor for neuropathic pain. Nature Medicine. 2015 May 7; 21(5): 429-30.
Weyer AD and Stucky CL. Loosening pain’s grip by tightening TRPV1-TRPA1 interactions. Neuron. 2015 Feb 18; 85(4):661-663
Lehto SG, Weyer AD, Zhang M, Youngblood BD, Wang J, Wang W, Kerstein PC, Davis C, Wild KD, Stucky CL, Gavva NR. AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia. Naunyn Schmiedebergs Arch Pharmacol. 2015 Apr; 388(4):465-76.
Chiu IM, Barrett LB, Williams EK, Strochlic DE, Lee S, Weyer AD, Lou S, Bryman G, Roberson DP, Ghasemlou N, Piccoli C, Ahat E, Wang V, Cobos EJ, Stucky CL, Ma Q, Liberles SD, Woolf C. Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity. eLife. 2014 Dec 19;4. doi: 10.7554/eLife.04660.
Woo SH, Ranade S, Weyer AD, Dubin AE, Baba Y, Qiu Z, Petrus M, Miyamoto T, Reddy K, Lumpkin EA, Stucky CL, Patapoutian A. Piezo2 is required for Merkel-cell mechanotransduction. Nature. 2014 May 29; 509(7502):622-6.
Garrison SR, Weyer AD, Barabas ME, Beutler BA, Stucky CL. A gain-of-function voltage-gated sodium channel 1.8 mutation drives intense hyperexcitability of A- and C-fiber neurons. Pain. 2014 May;155(5):896-905.
Hoeger Bement MK, Weyer A, Yoon T, Hunter SK. Corticomotor excitability during a noxious stimulus and after exercise in women with fibromyalgia. J Clin Neurophys. 2014 Feb;31(1):94-8
Hoeger Bement MK, Weyer A, Hartley S, Drewek B, Harkins A, Hunter SK. Pain perception after isometric exercise in women with fibromyalgia. Arch Phys Med Rehabil. 2011 Jan;92(1):89-95
Mantsch JR, Weyer A, Vranjkovic O, Beyer CE, Baker DA, Caretta H. Involvement of Noradrenergic Neurotransmission in the Stress- but not Cocaine-Induced Reinstatement of Extinguished Cocaine-Induced Conditioned Place Preference in Mice: Role for beta-2 Adrenergic Receptors. Neuropsychopharmacology. 2010 Oct;35(11):2165-78
Bement MH, Weyer A, Keller M, Harkins A, Hunter S. Anxiety and stress can predict pain perception following a cognitive stress. Physiol Behav. 2010 Aug 4;101(1):87-92.
Bement MKH, Weyer A, Hartley S, Yoon T, Hunter SK. Fatiguing exercise attenuates pain-induced corticomotor excitability. Neurosci Lett. 2009 Mar 13;452(2):209-13.
Weyer A. This will only hurt a bit: Activity of nociceptors depends on age and pain chronicity. Pacific University, Hillsboro, OR, April 2016.
Weyer A. Contribution of primary afferents and mechanosensitive ion channels to acute and chronic inflammatory pain. Medical College of Wisconsin, Milwaukee, WI. December 2015.
Weyer A. The aged and inflamed: Differential effects of acute and chronic pain on young and aged mice. University of Miami, Miami, FL. August 2015.
Weyer A and Zappia KJ. Patch Clamp Electrophysiology. National Institute on Drug Abuse (NIDA) workshop. Milwaukee, WI. July 2015.
Weyer A and Zappia KJ. Patch Clamp Electrophysiology. National Institute on Drug Abuse (NIDA) workshop. Milwaukee, WI. July 2014.
Weyer, A., O’Hara CL, and Stucky CL. Inflammation amplifies mechanical currents in cutaneous, CGRP-expressing sensory neurons. Mammalian Circuits Underlying Touch Sensation Meeting, Janelia Farms, VA. September 2013.
Weyer, A. and Stucky, C. Large diameter sensory neurons expressing CGRPα respond differentially to mechanical stimuli. Somatosensory Systems Nanosymposium, Society for Neuroscience 2012 Annual Meeting, New Orleans, LA. October 2012.
APTA Section on Research Abstract Reviewer for the Combined Sections Meeting. 2017
Lead Physical Therapist, Outside In Medical Clinic. Portland, OR. 2017-18
Salud! Migrant Workers Physical Therapy Outreach. Yamhill County, OR. 2015-17
Bread of Healing Free Medical Clinic. Milwaukee, WI.
Lead Physical Therapist, 2013-14
“Stepping On” Fall Prevention Course. 2012-13
Brain Awareness Day Coordinator
Medical College of Wisconsin. 2014
Brain Awareness Week Volunteer
Medical College of Wisconsin Brain Awareness Night. 2013
Ronald Reagan College Preparatory High School. 2012-13
Milwaukee Montessori Schools. 2011
Students Modeling A Research Topic (SMART) Team Mentor
Brown Deer High School. 2015-16
Divine Savior High School. 2014-15
Laconia High School. 2013-14
Milwaukee Public School District Science Fair Volunteer Judge. 2014-15
Pacific University Faculty Development Grant, Pilot Study on Low Intensity Exercise for Individuals with Fibromyalgia Award | 2016
Medical College of Wisconsin Graduate School of Biomedical Sciences
Outstanding Dissertation Award | 2016
Medical College of Wisconsin Neuroscience Research Center Travel Award | 2014
International Association for the Study of Pain (IASP) Travel Award | 2014
Medical College of Wisconsin Graduate Student Association Travel Award | 2012-2015
Marquette University Department of Physical Therapy Research Award | 2010
Marquette University Department of Physical Therapy Mary Pat Murray Award | 2010
Dr. Andy Weyer co-authored a study examining the effects of a novel pharmacological antagonist of the Transient Receptor Potential Ankyrin 1 (TRPA1) ion channel, which plays a role in pain sensation.
Andy is extremely excited to join the faculty in the School of Physical Therapy. He will be teaching Rehabilitation Neuroscience I and II, and will be co-teaching Patient Assessment, Intervention, and Therapeutic Modalities with Dr. Erin Jobst.